Braineos2

Electrophile, nucleophile

In a substitution reaction, the _ is attacked by the _

Polar aprotic

_ solvents favor Sn2 reactions

Primary, tertiary

Sn2 reactions happen fastest on _ electrophiles; and barely occur at all on _ electrophiles

Substrate

The "1" in "Sn1" means that the rate of reaction is dependent only on the concentration of the _

Sn1, Sn2

A _ reaction is much more sensitive to the stability of the leaving group than a _ reaction

Sn1

_ reactions need a polar solvent to stabilize the carbocation

Polar aprotic

Nucleophiles are always hindered by a solvent shell, except when they are in a _ solvent

Protonating

A bad leaving group can be converted into an excellent one by _ it

Acetone, DMSO, DME, DMF

The most common polar aprotic solvents are _, _, _, and _

Negative, stable

A good leaving group has a _ charge and is _

Polar aprotic

Acetone, DMSO, DME, and DMF are all _ solvents

Anionic, metal

Sn2 reactions need a good, _ nucleophile and a _ ion such as Na or K

Sn2

Polar aprotic solvents favor _ reactions

Steric hinderance, stability of charge

Sn2 reactions occur most readily on primary electrophiles due to less _; Sn2 reactions prefer tertiary electrophiles due to _

Negative, stable

A moderate nucleophile has a _ charge, and is very _

Polar

Sn1 reactions need a _ solvent to stabilize the carbocation

Polar

Sn2 reactions need a _ solvent to dissolve the nucleophile

Negative, stabilized, halogen

A strong nucleophile has a _ charge that is not _; and the charge is not on a _

1000

Sn2 reactions performed with nucleophiles in polar aprotic solvents occur about _ times faster than in regular protic solvents

Protic, nucleophile, solvolysis

In an Sn1 reaction, there is a _ solvent, which can also serve as the _; this is called _

Invert

Sn2 reactions _ the stereocenter

Negative, stabilized

A bad leaving group has a _ charge that is not _

Tertiary, primary

Sn1 reactions happen fastest on _ electrophiles; and barely occur on _ electrophiles

Sn1

The first step of a _ reaction is the loss of a leaving group

Solvent shell

A nucleophile with a negative charge, when dissolved in a polar solvent, will be surrounded by a _

Leaving group

The first step of an Sn1 reaction is the loss of a _

Neutral, positive

A weak nucleophile has a _ or _ charge

Racemic

Sn1 reactions produce _ mixtures

Substrate, nucleophile

The "2" in "Sn2" means that the rate of reaction is dependent on the concentrations of the _ and the _

Positive

For a leaving group to be neutral when it leaves, it must have a _ charge while it is still attached to the molecule.

Nucleophile

Sn2 reactions need a polar solvent to dissolve the _

Negative

An excellent leaving group does not have a _ charge

Negative

A nucleophile with a _ charge, when dissolved in a polar solvent, will be surrounded by asolvent shell




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